The Immunological Response of Hiv-Positive Patients Initiating Haart at the Komfo Anokye Teaching Hospital, Kumasi, Ghana
Identifieur interne : 000555 ( Main/Exploration ); précédent : 000554; suivant : 000556The Immunological Response of Hiv-Positive Patients Initiating Haart at the Komfo Anokye Teaching Hospital, Kumasi, Ghana
Auteurs : L. Annison [Ghana] ; A. Dompreh [Ghana] ; Y. Adu-Sarkodie [Ghana]Source :
- Ghana Medical Journal [ 0016-9560 ] ; 2013.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Charge virale (), Enquêtes et questionnaires, Femelle, Ghana, Humains, Hôpitaux d'enseignement, Lymphocytes T CD4+ (), Lymphocytes T CD4+ (immunologie), Mâle, Numération des lymphocytes CD4 (), Observance du traitement médicamenteux (), Pays en voie de développement, Résultat thérapeutique, Sujet âgé, Séropositivité VIH (immunologie), Séropositivité VIH (sang), Séropositivité VIH (traitement médicamenteux), Séropositivité VIH (virologie), Thérapie antirétrovirale hautement active (), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (immunologie).
- MESH :
- immunologie : Lymphocytes T CD4+, Séropositivité VIH, VIH-1 (Virus de l'Immunodéficience Humaine de type 1).
- sang : Séropositivité VIH.
- traitement médicamenteux : Séropositivité VIH.
- virologie : Séropositivité VIH.
- Adolescent, Adulte, Adulte d'âge moyen, Charge virale, Enquêtes et questionnaires, Femelle, Ghana, Humains, Hôpitaux d'enseignement, Lymphocytes T CD4+, Mâle, Numération des lymphocytes CD4, Observance du traitement médicamenteux, Pays en voie de développement, Résultat thérapeutique, Sujet âgé, Thérapie antirétrovirale hautement active, VIH-1 (Virus de l'Immunodéficience Humaine de type 1).
- Wicri :
- geographic : Ghana.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Antiretroviral Therapy, Highly Active (methods), CD4 Lymphocyte Count (methods), CD4-Positive T-Lymphocytes (drug effects), CD4-Positive T-Lymphocytes (immunology), Developing Countries, Female, Ghana, HIV Seropositivity (blood), HIV Seropositivity (drug therapy), HIV Seropositivity (immunology), HIV Seropositivity (virology), HIV-1 (drug effects), HIV-1 (immunology), Hospitals, Teaching, Humans, Male, Medication Adherence (statistics & numerical data), Middle Aged, Surveys and Questionnaires, Treatment Outcome, Viral Load (drug effects).
- MESH :
- geographic : Ghana.
- blood : HIV Seropositivity.
- drug effects : CD4-Positive T-Lymphocytes, HIV-1, Viral Load.
- drug therapy : HIV Seropositivity.
- immunology : CD4-Positive T-Lymphocytes, HIV Seropositivity, HIV-1.
- methods : Antiretroviral Therapy, Highly Active, CD4 Lymphocyte Count.
- statistics & numerical data : Medication Adherence.
- virology : HIV Seropositivity.
- Adolescent, Adult, Aged, Developing Countries, Female, Hospitals, Teaching, Humans, Male, Middle Aged, Surveys and Questionnaires, Treatment Outcome.
Abstract
The study sought to document the experience of immunological improvement among Ghanaian PLHIV on HAART comparing different categories of patients.
Serology Unit, Komfo Anokye Teaching Hospital, Kumasi, Ghana.
The study comprised a convenient sample of 303 treatment naïve HIV patients due to start HAART.
Questionnaires were used to collect patient demographic and clinical data. Four CD4 counts were measured at six-monthly intervals to determine rates of CD4 change. These were pre-therapy, 1st post-therapy, 2nd post-therapy, and 3rd post-therapy counts. The rates of CD4 change among the different categories of patients were also compared.
At baseline, women had higher CD4 count (mean of 77.4cells/°l), and mean age of participants was 40 years. The CD4 count increased from a mean baseline of 70.2 cells/°l to 229.2, 270.0, and 297.6 cells/°l at 6, 12, and 18 months of treatment respectively (
The study suggests that a sustained CD4 increase could be achieved in adherent patients commencing therapy with baseline CD4 count ≤250 cells/°l, and that these patients have greater ability for immunological recovery during 12 months of treatment The study, therefore, concludes that significant immunological improvement is possible among Ghanaian PLHIV on HAART as long as a high level of treatment adherence is observed.
Url:
PubMed: 24669021
PubMed Central: 3961850
Affiliations:
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Dompreh</name><affiliation wicri:level="1"><nlm:aff id="A2">Serology Unit, Department of Microbiology, Komfo Anokye Teaching Hospital, Kumasi, Ghana</nlm:aff><country xml:lang="fr">Ghana</country><wicri:regionArea>Serology Unit, Department of Microbiology, Komfo Anokye Teaching Hospital, Kumasi</wicri:regionArea><wicri:noRegion>Kumasi</wicri:noRegion></affiliation></author><author><name sortKey="Adu Sarkodie, Y" sort="Adu Sarkodie, Y" uniqKey="Adu Sarkodie Y" first="Y" last="Adu-Sarkodie">Y. 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Annison</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Clinical Microbiology, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana</nlm:aff><country xml:lang="fr">Ghana</country><wicri:regionArea>Department of Clinical Microbiology, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi</wicri:regionArea><wicri:noRegion>Kumasi</wicri:noRegion></affiliation></author><author><name sortKey="Dompreh, A" sort="Dompreh, A" uniqKey="Dompreh A" first="A" last="Dompreh">A. Dompreh</name><affiliation wicri:level="1"><nlm:aff id="A2">Serology Unit, Department of Microbiology, Komfo Anokye Teaching Hospital, Kumasi, Ghana</nlm:aff><country xml:lang="fr">Ghana</country><wicri:regionArea>Serology Unit, Department of Microbiology, Komfo Anokye Teaching Hospital, Kumasi</wicri:regionArea><wicri:noRegion>Kumasi</wicri:noRegion></affiliation></author><author><name sortKey="Adu Sarkodie, Y" sort="Adu Sarkodie, Y" uniqKey="Adu Sarkodie Y" first="Y" last="Adu-Sarkodie">Y. Adu-Sarkodie</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Clinical Microbiology, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana</nlm:aff><country xml:lang="fr">Ghana</country><wicri:regionArea>Department of Clinical Microbiology, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi</wicri:regionArea><wicri:noRegion>Kumasi</wicri:noRegion></affiliation></author></analytic><series><title level="j">Ghana Medical Journal</title><idno type="ISSN">0016-9560</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Antiretroviral Therapy, Highly Active (methods)</term><term>CD4 Lymphocyte Count (methods)</term><term>CD4-Positive T-Lymphocytes (drug effects)</term><term>CD4-Positive T-Lymphocytes (immunology)</term><term>Developing Countries</term><term>Female</term><term>Ghana</term><term>HIV Seropositivity (blood)</term><term>HIV Seropositivity (drug therapy)</term><term>HIV Seropositivity (immunology)</term><term>HIV Seropositivity (virology)</term><term>HIV-1 (drug effects)</term><term>HIV-1 (immunology)</term><term>Hospitals, Teaching</term><term>Humans</term><term>Male</term><term>Medication Adherence (statistics & numerical data)</term><term>Middle Aged</term><term>Surveys and Questionnaires</term><term>Treatment Outcome</term><term>Viral Load (drug effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Charge virale ()</term><term>Enquêtes et questionnaires</term><term>Femelle</term><term>Ghana</term><term>Humains</term><term>Hôpitaux d'enseignement</term><term>Lymphocytes T CD4+ ()</term><term>Lymphocytes T CD4+ (immunologie)</term><term>Mâle</term><term>Numération des lymphocytes CD4 ()</term><term>Observance du traitement médicamenteux ()</term><term>Pays en voie de développement</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Séropositivité VIH (immunologie)</term><term>Séropositivité VIH (sang)</term><term>Séropositivité VIH (traitement médicamenteux)</term><term>Séropositivité VIH (virologie)</term><term>Thérapie antirétrovirale hautement active ()</term><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) ()</term><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (immunologie)</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Ghana</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>HIV Seropositivity</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>CD4-Positive T-Lymphocytes</term><term>HIV-1</term><term>Viral Load</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>HIV Seropositivity</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Lymphocytes T CD4+</term><term>Séropositivité VIH</term><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1)</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>CD4-Positive T-Lymphocytes</term><term>HIV Seropositivity</term><term>HIV-1</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Antiretroviral Therapy, Highly Active</term><term>CD4 Lymphocyte Count</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Séropositivité VIH</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Medication Adherence</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Séropositivité VIH</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Séropositivité VIH</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>HIV Seropositivity</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Developing Countries</term><term>Female</term><term>Hospitals, Teaching</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Surveys and Questionnaires</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Charge virale</term><term>Enquêtes et questionnaires</term><term>Femelle</term><term>Ghana</term><term>Humains</term><term>Hôpitaux d'enseignement</term><term>Lymphocytes T CD4+</term><term>Mâle</term><term>Numération des lymphocytes CD4</term><term>Observance du traitement médicamenteux</term><term>Pays en voie de développement</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Thérapie antirétrovirale hautement active</term><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1)</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Ghana</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Summary</title><sec><title>Objective</title><p>The study sought to document the experience of immunological improvement among Ghanaian PLHIV on HAART comparing different categories of patients.</p></sec><sec><title>Setting</title><p>Serology Unit, Komfo Anokye Teaching Hospital, Kumasi, Ghana.</p></sec><sec><title>Participants</title><p>The study comprised a convenient sample of 303 treatment naïve HIV patients due to start HAART.</p></sec><sec sec-type="methods"><title>Methods</title><p>Questionnaires were used to collect patient demographic and clinical data. Four CD4 counts were measured at six-monthly intervals to determine rates of CD4 change. These were pre-therapy, 1<sup>st</sup> post-therapy, 2<sup>nd</sup> post-therapy, and 3<sup>rd</sup> post-therapy counts. The rates of CD4 change among the different categories of patients were also compared.</p></sec><sec sec-type="results"><title>Results</title><p>At baseline, women had higher CD4 count (mean of 77.4cells/°l), and mean age of participants was 40 years. The CD4 count increased from a mean baseline of 70.2 cells/°l to 229.2, 270.0, and 297.6 cells/°l at 6, 12, and 18 months of treatment respectively (<italic>P</italic> <0.0001 at each time point). There were no gender (<italic>P</italic>=0.46) and age (<italic>P</italic>=0.96) differences in treatment response. There was no difference (<italic>P</italic>=0.18) in treatment response comparing those with CD4 <250 cells/°l and those whose CD4 count was between 250 and 350 cells/°l at baseline although patients with baseline CD4 count <250 cells/°l showed larger increases after 12 months of treatment. Out of 282 patients with pre-therapy CD4 count "250 cells/°l, 241 (85.5%) and 41 (14.5%) were adherents and nonadherents respectively. Mean rate of increase was 15.2 and 8.4 cells/°l/month in adherent and non-adherent patients respectively (<italic>p</italic>=0.2).</p></sec><sec sec-type="conclusions"><title>Conclusion</title><p>The study suggests that a sustained CD4 increase could be achieved in adherent patients commencing therapy with baseline CD4 count ≤250 cells/°l, and that these patients have greater ability for immunological recovery during 12 months of treatment The study, therefore, concludes that significant immunological improvement is possible among Ghanaian PLHIV on HAART as long as a high level of treatment adherence is observed.</p></sec></div></front></TEI><affiliations><list><country><li>Ghana</li></country></list><tree><country name="Ghana"><noRegion><name sortKey="Annison, L" sort="Annison, L" uniqKey="Annison L" first="L" last="Annison">L. Annison</name></noRegion><name sortKey="Adu Sarkodie, Y" sort="Adu Sarkodie, Y" uniqKey="Adu Sarkodie Y" first="Y" last="Adu-Sarkodie">Y. Adu-Sarkodie</name><name sortKey="Dompreh, A" sort="Dompreh, A" uniqKey="Dompreh A" first="A" last="Dompreh">A. Dompreh</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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